Schmidt-Ott Lab

Clogmia albipunctata

The mothfly Clogmia albipunctata (syn. Telmatoscopus albipunctatus) is a cosmopolitan saprophagous midge. The species is very easy to keep in the laboratory and has a generation time of  ~4 weeks at 25 C. The genome of Clogmia albipunctata (ca.316 Mb in both sexes; Schmidt-Ott et al. 2009) has been sequenced (

Check out Clogmia in the "wild"

PBS show Deep Look featured Clogmia in a recent video. Urs and Koray were consulted, and the Schmidt-Ott lab also provided the fly culture used in the filming!

Clogmia albipunctata adult

Clogmia albipunctata first instar larva

Knockdown of odd-paired in Clogmia albipunctata first instar larva leads to double abdomen phenotype.

Selected References:

Embryo polarity in moth flies and mosquitoes relies on distinct old genes with localized transcript isoforms. Yoon Y, Klomp J, Martin-Martin I, Criscione F, Calvo E, Ribeiro J, Schmidt-Ott U. Elife. 2019 Oct 8;8. pii: e46711. doi: 10.7554/eLife.46711. PMID:31591963

A staging scheme for the development of the moth midge Clogmia albipunctata. Jiménez-Guri E, Wotton KR, Gavilán B, Jaeger J. PLoS One. 2014 Jan 7;9(1):e84422. doi: 10.1371/journal.pone.0084422. eCollection 2014. PMID:24409296

A single Hox3 gene with composite bicoid and zerknullt expression characteristics in non-Cyclorrhaphan flies. Stauber M, Prell A, Schmidt-Ott U. Proceedings of the National Academy of Sciences of the United States of America. 2002; 99(1):274-9.
PMID:11773616, PMCID:PMC117551

Differential cytoplasmic mRNA localisation adjusts pair-rule transcription factor activity to cytoarchitecture in dipteran evolution. Bullock SL, Stauber M, Prell A, Hughes JR, Ish-Horowicz D, Schmidt-Ott U. Development. 2004; 131(17):4251-61.

Extremely small genomes in two unrelated dipteran insects with shared early developmental traits. Schmidt-Ott U, Rafiqi AM, Sander K, Johnston JS. Development Genes and Evolution. 2009; 219(4):207-10.

Expression of engrailed in embryos of a beetle and five dipteran species with special reference to the terminal regions. Schmidt-Ott U, Sander K, Technau GM. Roux’s Archives of Developmental Biology. 1994; 203(6):298-303. PMID:28305822